P174E Substitution in GES-1 and GES-5 beta-Lactamases Improves Catalytic Efficiency toward Carbapenems

Piccirilli, A; Mercuri, PS; Galleni, M; Aschi, M; Matagne, A; Amicosante, G; Perilli, M

Perilli, M (reprint author), Univ Aquila, Dipartimento Sci Clin Applicate & Biotecnol, Laquila, Italy.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2018; 62 (5):

Abstract

GES-type beta-lactamases are a group of enzymes that have evolved their hydrolytic activity against carbapenems. In this study, the role of residue 17......

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