VHL regulates the sensitivity of clear cell renal cell carcinoma to SIRT4-mediated metabolic stress via HIF-1 alpha/HO-1 pathway

Tong, Y; Kai, JY; Wang, S; Yu, YW; Xie, SH; Zheng, H; Wang, YC; Liu, YX; Zhu, KY; Guan, XL; Guo, L; Lu, RQ

Guo, L; Lu, RQ (corresponding author), Fudan Univ, Shanghai Canc Ctr, Dept Clin Lab, Shanghai, Peoples R China.; Guo, L; Lu, RQ (corresponding author), Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China.

CELL DEATH & DISEASE, 2021; 12 (7):

Abstract

Clear cell renal cell carcinomas (ccRCC) reprogram carbon metabolism responses to hypoxia, thereby promoting utilization of glutamine. Recently, sirtu......

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