Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells

Skalniak, L; Zak, KM; Guzik, K; Magiera, K; Musielak, B; Pachota, M; Szelazek, B; Kocik, J; Grudnik, P; Tomala, M; Krzanik, S; Pyrc, K; Domling, A; Dubin, G; Holak, TA

Holak, TA (reprint author), Jagiellonian Univ, Dept Organ Chem, Fac Chem, PL-30060 Krakow, Poland.; Dubin, G (reprint author), Jagiellonian Univ, Malopolska Ctr Biotechnol, PL-30387 Krakow, Poland.; Dubin, G (reprint author), Jagiellonian Univ, Fac Bioche

ONCOTARGET, 2017; 8 (42): 72167

Abstract

Antibodies targeting the PD-1/PD-L1 immune checkpoint achieved spectacular success in anticancer therapy in the recent years. In contrast, no small mo......

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