Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer

Udupa, S; Nguyen, S; Hoang, G; Nguyen, T; Quinones, A; Pham, K; Asaka, R; Nguyen, K; Zhang, C; Elgogary, A; Jung, JG; Xu, QG; Fu, J; Thomas, AG; Tsukamoto, T; Hanes, J; Slusher, BS; Cooper, AL; Le, A

Le, A (reprint author), Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA.

PROTEOMICS, 2019; 19 (21-22):

Abstract

The targeting of glutamine metabolism specifically via pharmacological inhibition of glutaminase 1 (GLS1) has been translated into clinical trials as ......

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