Design, synthesis and biological evaluation of novel O-substituted tryptanthrin oxime derivatives as c-Jun N-terminal kinase inhibitors

Schepetkin, IA; Kovrizhina, AR; Stankevich, KS; Khlebnikov, AI; Kirpotina, LN; Quinn, MT; Cook, MJ

Quinn, MT (通讯作者),Montana State Univ, Dept Microbiol & Cell Biol, Bozeman, MT 59717 USA.;Cook, MJ (通讯作者),Montana State Univ, Dept Chem & Biochem, Bozeman, MT 59717 USA.

FRONTIERS IN PHARMACOLOGY, 2022; 13 ():

Abstract

The c-Jun N-terminal kinase (JNK) family includes three proteins (JNK1-3) that regulate many physiological processes, including inflammatory responses......

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