Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity

Yao, H; Liu, MH; Wang, LB; Zu, YM; Wu, C; Li, CY; Zhang, RX; Lu, HG; Li, FF; Xi, S; Chen, SQ; Gu, XY; Liu, TY; Cai, J; Wang, SR; Yang, MJ; Xing, GG; Xiong, W; Hua, L; Tang, YF; Wang, GL

Tang, YF; Wang, GL (通讯作者)，Tsinghua Univ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Sch Pharmaceut Sci, Beijing Adv Innovat Ctr Struct Biol,Minist Educ, Beijing, Peoples R China.

CELL RESEARCH, 2022; 32 (6): 570

Abstract

The decline of nicotinamide adenine dinucleotide (NAD) occurs in a variety of human pathologies including neurodegeneration. NAD-boosting agents can p......

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