Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation

Hammill, JT; Bhasin, D; Scott, DC; Min, J; Chen, YZ; Lu, Y; Yang, L; Kim, HS; Connelly, MC; Hammill, C; Holbrook, G; Jeffries, C; Singh, B; Schulman, BA; Guy, RK

Guy, RK (reprint author), St Jude Childrens Res Hosp, Dept Chem Biol & Theraput, 332 N Lauderdale St, Memphis, TN 38105 USA.; Guy, RK (reprint author), Univ Kentucky, Dept Pharmaceut Sci, 789 South Limestone, Lexington, KY 40508 USA.

JOURNAL OF MEDICINAL CHEMISTRY, 2018; 61 (7): 2694

Abstract

We previously reported the discovery, validation, and structure-activity relationships of a series of piperidinyl ureas that potently inhibit the DCN1......

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