Deficiency of IRG1/itaconate aggravates endotoxemia-induced acute lung injury by inhibiting autophagy in mice

Qiu, JH; Zhang, L; Li, KX; Zhang, QH; Fan, KR; Chen, K; Jiang, Y; Liu, G

Liu, G (通讯作者)，Chongqing Med Univ, Dept Emergency & Crit Care Med, Univ Town Hosp, 55 Middle Rd, Chongqing 401331, Peoples R China.;Jiang, Y (通讯作者)，Chongqing Med Univ, Univ Town Hosp, Dept Resp & Crit Care Med, Middle Rd, Chongqing 401331, Peoples R China.

EXPERIMENTAL ANIMALS, 2023; 72 (2): 164

Abstract

Itaconate, produced by aconitate decarboxylase 1 (ACOD1), which is encoded by immune-responsive gene 1 (Irg1), is one of the metabolites derived from ......

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