Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis

Anthonymuthu, TS; Tyurina, YY; Sun, WY; Mikulska-Ruminska, K; Shrivastava, IH; Tyurin, VA; Cinemre, FB; Dar, HH; VanDemark, AP; Holman, TR; Sadovsky, Y; Stockwell, BR; He, RR; Bahar, I; Bayir, H; Kagan, VE

Kagan, VE (corresponding author), Room 4120,130 De Soto St, Pittsburgh, PA 15219 USA.; Bayir, H (corresponding author), Childrens Hosp Pittsburgh, 4401 Penn Ave, Pittsburgh, PA 15224 USA.

REDOX BIOLOGY, 2021; 38 ():

Abstract

Hydroperoxy-eicosatetraenoyl-phosphatidylethanolamine (HpETE-PE) is a fermptotic cell death signal. HpETE-PE is produced by the 15-Lipoxygenase (15LOX......

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