Phase I clinical trial of temsirolimus and perifosine for recurrent glioblastoma

Kaley, TJ; Panageas, KS; Pentsova, EI; Mellinghoff, IK; Nolan, C; Gavrilovic, I; DeAngelis, LM; Abrey, LE; Holland, EC; Omuro, A; Lacouture, ME; Ludwig, E; Lassman, AB

Kaley, TJ (corresponding author), Mem Sloan Kettering Canc Ctr, Dept Neurol, 1275 York Ave, New York, NY 10021 USA.; Lassman, AB (corresponding author), Columbia Univ, Irving Med Ctr, Dept Neurol, 710 West 168th St, New York, NY 10032 USA.; Lassman, AB (corresponding author), Columbia Univ, Irving Med Ctr, Herbert Irving Comprehens Canc Ctr, 710 West 168th St, New York, NY 10032 USA.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, 2020; 7 (4): 429

Abstract

Purpose Malignant glioma (MG) is the most deadly primary brain cancer. Signaling though the PI3K/AKT/mTOR axis is activated in most MGs and therefore ......

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