The LSD1 inhibitor iadademstat (ORY-1001) targets SOX2-driven breast cancer stem cells: a potential epigenetic therapy in luminal-B and HER2-positive breast cancer subtypes

Cuyas, E; Gumuzio, J; Verdura, S; Brunet, J; Bosch-Barrera, J; Martin-Castillo, B; Alarcon, T; Encinar, JA; Martin, AG; Menendez, JA

Menendez, JA (corresponding author), Catalan Inst Oncol, Metab & Canc Grp, Program Canc Therapeut Resistance ProCURE, Girona, Spain.; Menendez, JA (corresponding author), Girona Biomed Res Inst IDIBGI, Girona, Spain.

AGING-US, 2020; 12 (6): 4794

Abstract

SOX2 is a core pluripotency-associated transcription factor causally related to cancer initiation, aggressiveness, and drug resistance by driving the ......

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