Antidepressant-like effect of zileuton is accompanied by hippocampal neuroinflammation reduction and CREB/BDNF upregulation in lipopolysaccharide-challenged mice

Li, DD; Xie, H; Du, YF; Long, Y; Reed, MN; Hu, M; Suppiramaniam, V; Hong, H; Tang, SS

Hong, H; Tang, SS (reprint author), China Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Peoples R China.

JOURNAL OF AFFECTIVE DISORDERS, 2018; 227 (): 672

Abstract

Background: Recent studies demonstrated beneficial effects of zileuton, a 5-lipoxygenase (5LO) inhibitor, on some brain diseases in animal models, but......

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