Validated biomarker assays confirm that ARID1A loss is confounded with MMR deficiency, CD8(+) TIL infiltration, and provides no independent prognostic value in endometriosis-associated ovarian carcinomas

Heinze, K; Nazeran, TM; Lee, S; Kramer, P; Cairns, ES; Chiu, DS; Leung, SCY; Kang, EY; Meagher, NS; Kennedy, CJ; Boros, J; Kommoss, F; Vollert, HW; Heitze, F; du Bois, A; Harter, P; Grube, M; Kraemer, B; Staebler, A; Kommoss, FKF; Heublein, S; Sinn, HP; Singh, N; Laslavic, A; Elishaev, E; Olawaiye, A; Moysich, K; Modugno, F; Sharma, R; Brand, AH; Harnett, PR; DeFazio, A; Fortner, RT; Lubinski, J; Lener, M; Toloczko-Grabarek, A; Cybulski, C; Gronwald, H; Gronwald, J; Coulson, P; El-Bahrawy, MA; Jones, ME; Schoemaker, MJ; Swerdlow, AJ; Gorringe, KL; Campbell, I; Cook, L; Gayther, SA; Carney, ME; Shvetsov, YB; Hernandez, BY; Wilkens, LR; Goodman, MT; Mateoiu, C; Linder, A; Sundfeldt, K; Kelemen, LE; Gentry-Maharaj, A; Widschwendter, M; Menon, U; Bolton, KL; Alsop, J; Shah, M; Jimenez-Linan, M; Pharoah, PDP; Brenton, JD; Cushing-Haugen, KL; Harris, HR; Doherty, JA; Gilks, B; Ghatage, P; Huntsman, DG; Nelson, GS; Tinker, AV; Lee, CH; Goode, EL; Nelson, BH; Ramus, SJ; Kommoss, S; Talhouk, A; Kobel, M; Anglesio, MS

Anglesio, MS (通讯作者),Univ British Columbia, Dept Obstet & Gynecol, 2660 Oak St, Vancouver, BC V6H 3Z6, Canada.;Anglesio, MS (通讯作者),Univ British Columbia, Vancouver Gen Hosp & BC Canc, British Columbias Gynecol Canc Res Team OVCARE, Vancouver, BC, Canada.;Kobel, M (通讯作者),Univ Calgary, Dept Pathol & Lab Med, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada.

JOURNAL OF PATHOLOGY, 2022; 256 (4): 388

Abstract

ARID1A (BAF250a) is a component of the SWI/SNF chromatin modifying complex, plays an important tumour suppressor role, and is considered prognostic in......

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