Therapeutic Activity of the Lansoprazole Metabolite 5-Hydroxy Lansoprazole Sulfide in Triple-Negative Breast Cancer by Inhibiting the Enoyl Reductase of Fatty Acid Synthase

Beebe, J; Josephraj, S; Wang, CJ; Danielson, J; Cui, QB; Huang, CQL; Barlow, L; Zhang, RH; Zhang, TL; Nakshatri, H; Dong, ZZ; Li, XH; Liu, JY; Zhang, JT

Zhang, JT (通讯作者),Univ Toledo, Dept Cell & Canc Biol, Coll Med & Life Sci, Toledo, OH 43614 USA.

JOURNAL OF MEDICINAL CHEMISTRY, 2022; 65 (20): 13681

Abstract

Fatty acid synthase (FASN), a sole cytosolic enzyme responsible for de-novo lipid synthesis, is overexpressed in cancer but not in normal non-lipogeni......

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