Overexpression of TopBP1, a canonical ATR/Chk1 activator, paradoxically hinders ATR/Chk1 activation in cancer

Liu, K; Graves, JD; Lin, FT; Lin, WC

Lin, WC (corresponding author), Baylor Coll Med, Sect Hematol Oncol, Dept Med, Houston, TX 77030 USA.; Lin, WC (corresponding author), Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA.

JOURNAL OF BIOLOGICAL CHEMISTRY, 2021; 296 ():

Abstract

Topoisomerase II beta-binding protein 1 (TopBP1) is involved in cellular replication among other functions and is known to activate ATR/Chk1 during re......

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