Alzheimer-like tau accumulation in dentate gyrus mossy cells induces spatial cognitive deficits by disrupting multiple memory-related signaling and inhibiting local neural circuit

Li, SH; Zhou, QZ; Liu, EJ; Du, HY; Yu, NN; Yu, HT; Wang, WJ; Li, MZ; Weng, Y; Gao, Y; Pi, GL; Wang, X; Ke, D; Wang, JZ

Wang, JZ (通讯作者)，Huazhong Univ Sci & Technol, Key Lab Educ Minist China Hubei Prov Neurol Disor, Dept Pathophysiol, Sch Basic Med,Tongji Med Coll, Wuhan 430030, Peoples R China.;Liu, EJ (通讯作者)，Zhengzhou Univ, Dept Pathol, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China.

AGING CELL, 2022; 21 (5):

Abstract

Abnormal tau accumulation and spatial memory loss constitute characteristic pathology and symptoms of Alzheimer disease (AD). Yet, the intrinsic conne......

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