The importance of FcRn in neuro-immunotherapies: From IgG catabolism, FCGRT gene polymorphisms, IVIg dosing and efficiency to specific FcRn inhibitors

Dalakas, MC; Spaeth, PJ

Dalakas, MC (corresponding author), Thomas Jefferson Univ, 900 Walnut St, Philadelphia, PA 19107 USA.; Dalakas, MC (corresponding author), Natl & Kapodistrian Univ Athens, Neuroimmunol Unit, Athens, Greece.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS, 2021; 14 ():

Abstract

The neonatal Fc receptor (FcRn) binds endogenous IgG and protects it from lysosomal degradation by transporting it back to the cell surface to re-ente......

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