TIGIT signaling restores suppressor function of Th1 Tregs

Lucca, LE; Axisa, PP; Singer, ER; Nolan, NM; Dominguez-Villar, M; Hafler, DA

Dominguez-Villar, M (reprint author), Yale Sch Med, Dept Neurol, 15 York St, New Haven, CT 06520 USA.; Dominguez-Villar, M (reprint author), Yale Sch Med, Dept Immunobiol, 15 York St, New Haven, CT 06520 USA.; Dominguez-Villar, M (reprint author), Imperia

JCI INSIGHT, 2019; 4 (3):

Abstract

Th1 Tregs are characterized by the acquisition of proinflammatory cytokine secretion and reduced suppressor activity. Th1 Tregs are found at increased......

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