Developing a physiologically based pharmacokinetic model of apixaban to predict scenarios of drug-drug interactions, renal impairment and paediatric populations

Xu, RJ; Tang, H; Chen, L; Ge, WH; Yang, J

Ge, WH (corresponding author), Nanjing Univ, Dept Pharm, Med Sch, Drum Tower Hosp, Zhongshan Rd 321, Nanjing 210008, Peoples R China.; Yang, J (corresponding author), China Pharmaceut Univ, Ctr Drug Metab & Pharmacokinet, 24 Tong Jia Xiang, Nanjing 210008, Peoples R China.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2021; 87 (8): 3244

Abstract

Aims: To develop a physiologically based pharmacokinetic (PBPK) model for apixaban, an oral anticoagulant with a narrow therapeutic index, and to pred......

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