Phase 3 Trial of Interleukin-1 Trap Rilonacept in Recurrent Pericarditis

Klein, AL; Imazio, M; Cremer, P; Brucato, A; Abbate, A; Fang, F; Insalaco, A; LeWinter, M; Lewis, BS; Lin, D; Luis, SA; Nicholls, SJ; Pano, A; Wheeler, A; Paolini, JF

Klein, AL (corresponding author), Cleveland Clin, Ctr Diag & Treatment Pericardial Dis, Sect Cardiovasc Imaging, Dept Cardiovasc Med,Heart Vasc & Thorac Inst, 9500 Euclid Ave,Desk J1-5, Cleveland, OH 44195 USA.; Imazio, M (corresponding author), AOU Citta Salute & Sci Torino, Univ Cardiol Cardiovasc & Thorac Dept, Corso Bramante 88, I-10126 Turin, Italy.

NEW ENGLAND JOURNAL OF MEDICINE, 2021; 384 (1): 31

Abstract

BACKGROUND Interleukin-1 has been implicated as a mediator of recurrent pericarditis. The efficacy and safety of rilonacept, an interleukin-1 alpha an......

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