Trial of SAGE-217 in Patients with Major Depressive Disorder

Gunduz-Bruce, H; Silber, C; Kaul, I; Rothschild, AJ; Riesenberg, R; Sankoh, AJ; Li, HH; Lasser, R; Zorumski, CF; Rubinow, DR; Paul, SM; Jonas, J; Doherty, JJ; Kanes, SJ

Gunduz-Bruce, H (reprint author), Sage Therapeut, 215 First St, Cambridge, MA 02142 USA.

NEW ENGLAND JOURNAL OF MEDICINE, 2019; 381 (10): 903

Abstract

Background Altered neurotransmission of gamma-aminobutyric acid (GABA) has been implicated in the pathogenesis of depression. Whether SAGE-217, an ora......

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