Inherent DNA-binding specificities of the HIF-1 alpha and HIF-2 alpha transcription factors in chromatin

Smythies, JA; Sun, M; Masson, N; Salama, R; Simpson, PD; Murray, E; Neumann, V; Cockman, ME; Choudhry, H; Ratcliffe, PJ; Mole, DR

Ratcliffe, PJ; Mole, DR (reprint author), Univ Oxford, NDM Res Bldg, Oxford, England.; Ratcliffe, PJ (reprint author), Francis Crick Inst, London, England.

EMBO REPORTS, 2019; 20 (1):

Abstract

Hypoxia-inducible factor (HIF) is the major transcriptional regulator of cellular responses to hypoxia. The two principal HIF-alpha isoforms, HIF-1 al......

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