Titanium Tetrachloride-Mediated Approach to Access 2-Chloro-2-Substituted Isoindolin-1-ones through the Addition of Alkynes to Acyliminium ions

Xu, WK; Guo, JM; Chen, ZD; Si, CM; Wei, BG

Si, CM; Wei, BG (corresponding author), Fudan Univ, Sch Pharm, Dept Nat Med, 826 Zhangheng Rd, Shanghai 201203, Peoples R China.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2021; 2021 (18): 2625

Abstract

An asymmetric approach to access 2-substituted isoindolin-1-ones 9-11 was developed through TiCl4-mediated addition-chlorination of N,O-acetals 7 a-7 ......

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