The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk

Deming, Y; Filipello, F; Cignarella, F; Cantoni, C; Hsu, S; Mikesell, R; Li, ZR; Del-Aguila, JL; Dube, U; Farias, FG; Bradley, J; Budde, J; Ibanez, L; Fernandez, MV; Blennow, K; Zetterberg, H; Heslegrave, A; Johansson, PM; Svensson, J; Nellgard, B; L

Karch, CM; Cruchaga, C (reprint author), Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA.; Piccio, L (reprint author), Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA.; Karch, CM; Piccio, L; Cruchaga, C (reprint author), Wash

SCIENCE TRANSLATIONAL MEDICINE, 2019; 11 (505):

Abstract

Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal fluid (CSF) has been associated with Alzheimer's disease (AD). TREM......

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