Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7

Bang, SS; Yoo, J; Gong, XR; Liu, D; Han, QJ; Luo, X; Chang, W; Chen, G; Im, ST; Kim, YH; Strong, J; Zhang, MZ; Zhang, JM; Lee, SY; Ji, RR

Ji, RR (reprint author), Duke Univ, Dept Anesthesiol, Med Ctr, 595 LaSalle St, Durham, NC 27710 USA.; Lee, SY (reprint author), Duke Univ, Dept Biochem, Med Ctr, 303 Res Dr, Durham, NC 27710 USA.; Zhang, JM (reprint author), Univ Cincinnati, Dept Anesthes

NEUROSCIENCE BULLETIN, 2018; 34 (1): 22

Abstract

The voltage-gated Na+ channel subtype Nav1.7 is important for pain and itch in rodents and humans. We previously showed that a Nav1.7-targeting monocl......

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