Synthesis of novel 1H-Pyrazolo[3,4-b]pyridine derivatives as DYRK 1A/ 1B inhibitors

Park, A; Hwang, J; Lee, JY; Heo, EJ; Na, YJ; Kang, S; Jeong, KS; Kim, KY; Shin, SJ; Lee, H

Lee, H (corresponding author), Korea Res Inst Chem Technol, Infect Dis Therapeut Res Ctr, Daejeon 34114, South Korea.; Kim, KY; Lee, H (corresponding author), Chungnam Natl Univ, Grad Sch New Drug Discovery & Dev, Daejeon 34134, South Korea.; Shin, SJ (corresponding author), Yonsei Univ, Coll Med, Songdang Inst Canc Res, Seoul 03722, South Korea.; Shin, SJ (corresponding author), Yonsei Univ, Coll Med, Yonsei Canc Ctr, Div Med Oncol,Dept Internal Med, Seoul 03722, South Korea.; Kim, KY (correspo

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021; 47 ():

Abstract

As DYRK1A and 1B inhibitors, 1H-pyrazolo[3,4-b]pyridine derivatives were synthesized. Mostly, 3-aryl-5-arylamino compounds (6) and 3,5-diaryl compound......

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