Intradiscal delivery of celecoxib-loaded microspheres restores intervertebral disc integrity in a preclinical canine model

Tellegen, AR; Rudnik-Jansen, I; Beukers, M; Miranda-Bedate, A; Bach, FC; de Jong, W; Woike, N; Mihov, G; Thies, JC; Meij, BP; Creemers, LB; Tryfonidou, MA

Tryfonidou, MA (reprint author), Fac Vet Med Utrecht, Yalelaan 108, NL-3584 CM Utrecht, Netherlands.

JOURNAL OF CONTROLLED RELEASE, 2018; 286 (): 439

Abstract

Low back pain, related to degeneration of the intervertebral disc (IVD), affects millions of people worldwide. Clinical studies using oral cyclooxygen......

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