Screening strategy of TMPRSS2 inhibitors by FRET-based enzymatic activity for TMPRSS2-based cancer and COVID-19 treatment

Chen, Y; Huang, WC; Yang, CS; Cheng, FJ; Chiu, YF; Chen, HF; Huynh, TK; Huang, CF; Chen, CH; Wang, HC; Hung, MECE

Hung, MECE (corresponding author), China Med Univ, 100,Sec 1,Jingmao Rd, Taichung 406, Taiwan.

AMERICAN JOURNAL OF CANCER RESEARCH, 2021; 11 (3): 827

Abstract

Transmembrane serine protease (TMPRSS2) plays an oncogenic role in prostate cancer as the fusion gene with ERG, and has also been demonstrated to be e......

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