Andrographolide inhibits hypoxia-induced HIF-1-driven endothelin 1 secretion by activating Nrf2/HO-1 and promoting the expression of prolyl hydroxylases 2/3 in human endothelial cells

Lin, HC; Su, SL; Lu, CY; Lin, AH; Lin, WC; Liu, CS; Yang, YC; Wang, HM; Lii, CK; Chen, HW

Lii, CK; Chen, HW (reprint author), China Med Univ, Dept Nutr, Taichung, Taiwan.; Lii, CK (reprint author), Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung, Taiwan.

ENVIRONMENTAL TOXICOLOGY, 2017; 32 (3): 918

Abstract

Andrographolide, the main bioactive component of the medicinal plant Andrographis paniculata, has been shown to possess potent anti-inflammatory activ......

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