Ancient familial Mediterranean fever mutations in human pyrin and resistance toYersinia pestis

Park, YH; Remmers, EF; Lee, W; Ombrello, AK; Chung, LK; Zhao, SL; Stone, DL; Ivanov, MI; Loeven, NA; Barron, KS; Hoffmann, P; Nehrebecky, M; Akkaya-Ulum, YZ; Sag, E; Balci-Peynircioglu, B; Aksentijevich, I; Gul, A; Rotimi, CN; Chen, H; Bliska, JB; Ozen, S; Kastner, DL; Shriner, D; Chae, JJ

Kastner, DL; Chae, JJ (corresponding author), NHGRI, Inflammatory Dis Sect, Metab Cardiovasc & Inflammatory Dis Genom Branch, Bethesda, MD 20892 USA.

NATURE IMMUNOLOGY, 2020; 21 (8): 857

Abstract

Familial Mediterranean fever is an autoinflammatory disease caused by gain-of-function mutations in the pyrin inflammasome. Kastner and colleagues sho......

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