Does Ras Activate Raf and PI3K Allosterically?

Nussinov, R; Tsai, CJ; Jang, H

Nussinov, R (reprint author), NCI, Canc & Inflammat Program, Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Frederick, MD 21701 USA.; Nussinov, R (reprint author), Tel Aviv Univ, Sackler Sch Med, Dept Human Mol Genet & Biochem, Tel Aviv, Israel.

FRONTIERS IN ONCOLOGY, 2019; 9 ():

Abstract

The mechanism through which oncogenic Ras activates its effectors is vastly important to resolve. If allostery is at play, then targeting allosteric p......

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