Metabolism and Interspecies Variation of IMMH-010, a Programmed Cell Death Ligand 1 Inhibitor Prodrug

Wang, YC; Liu, X; Zou, XW; Wang, ST; Luo, LJ; Liu, YK; Dong, K; Yao, XQ; Li, Y; Chen, XG; Sheng, L

Chen, XG (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing Key Lab Act Subst Discovery & Druggabil E, 1 Xian Nong Tan St, Beijing 100050, Peoples R China.; Chen, XG; Sheng, L (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, 1 Xian Nong Tan St, Beijing 100050, Peoples R China.; Sheng, L (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing

PHARMACEUTICS, 2021; 13 (5):

Abstract

IMMH-010 is an ester prodrug of YPD-29B, a potent programmed cell death ligand 1 (PD-L1) inhibitor. The metabolism of IMMH-010 was investigated and co......

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