PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As2O3 by stabilizing oncoprotein PML-RAR alpha

Huang, XP; Yang, YF; Zhu, D; Zhao, Y; Wei, M; Li, K; Zhu, HH; Zheng, XF

Zheng, XF (通讯作者)，Peking Univ, Sch Life Sci, State Key Lab Prot & Plant Gene Res, Beijing 100871, Peoples R China.;Zheng, XF (通讯作者)，Peking Univ, Sch Life Sci, Dept Biochem & Mol Biol, Beijing, Peoples R China.

CELLULAR AND MOLECULAR LIFE SCIENCES, 2022; 79 (6):

Abstract

Acute promyelocytic leukemia (APL) is a hematological malignancy driven by the oncoprotein PML-RAR alpha, which can be treated with arsenic trioxide (......

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