Structure of GPR101-Gs enables identification of ligands with rejuvenating potential

Yang, Z; Wang, JY; Yang, F; Zhu, KK; Wang, GP; Guan, Y; Ning, SL; Lu, Y; Li, Y; Zhang, C; Zheng, Y; Zhou, SH; Wang, XW; Wang, MW; Xiao, P; Yi, F; Zhang, C; Zhang, PJ; Xu, F; Liu, BH; Zhang, H; Yu, X; Gao, N; Sun, JP

Sun, JP (通讯作者),Shandong Univ, Cheeloo Coll Med, Sch Basic Med Sci, Dept Biochem & Mol Biol, Jinan 250012, Shandong, Peoples R China.;Sun, JP (通讯作者),Shandong Univ, Qilu Hosp, NHC Key Lab Otorhinolaryngol, Jinan, Peoples R China.;Sun, JP (通讯作者),Beijing Key Lab Cardiovasc Receptors Res, Beijing, Peoples R China.;Sun, JP (通讯作者),Shandong Univ, Adv Med Res Inst, Cheeloo Coll Med, Meili Lake Translat Res Pk, Jinan, Peoples R China.;Yu, X (通讯作者),Shandong Univ, Cheeloo Coll Med, Sch Bas Med Sci, Key Lab Expt Teratol,Minist Educ,Dept Physiol, Jinan, Peoples R China.;Gao, N (通讯作者),Peking Univ, Peking Tsinghua Joint Ctr Life Sci, Sch Life Sci, State Key Lab Membrane Biol, Beijing, Peoples R China.;Sun, JP (通讯作者),Peking Univ, Sch Bas Med Sci, Key Lab Mol Cardiovasc Sci, Dept Physiol & Pathophysiol,Minist Educ, Beijing, Peoples R China.

NATURE CHEMICAL BIOLOGY, 2023; ():

Abstract

GPR101 is an orphan G protein-coupled receptor actively participating in energy homeostasis. Here we report the cryo-electron microscopy structure of ......

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