Allosteric inhibitors hit USP7 hard

Zhang, W; Sidhu, SS

Sidhu, SS (reprint author), Univ Toronto, Banting & Best Dept Med Res, Donnelly Ctr Cellular & Biomol Res, Toronto, ON, Canada.; Sidhu, SS (reprint author), Univ Toronto, Dept Mol Genet, Toronto, ON, Canada.

NATURE CHEMICAL BIOLOGY, 2018; 14 (2): 110

Abstract

A potent and specific small-molecule inhibitor of a long-sought-after anticancer drug target, USP7, that acts allosterically to inhibit MDM2-stabilizi......

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