A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression

Workman, RE; Pammi, T; Nguyen, BTK; Graeff, LW; Smith, E; Sebald, SM; Stoltzfus, MJ; Euler, CW; Modell, JW

Modell, JW (corresponding author), Johns Hopkins Univ, Dept Mol Biol & Genet, Sch Med, Baltimore, MD 21205 USA.

CELL, 2021; 184 (3): 675

Abstract

CRISPR-Cas systems provide prokaryotes with acquired immunity against viruses and plasmids, but how these systems are regulated to prevent autoimmunit......

Full Text Link