Pan-RAS inhibitors: Hitting multiple RAS isozymes with one stone

Coley, AB; Ward, A; Keeton, AB; Chen, X; Maxuitenko, Y; Prakash, A; Li, F; Foote, JB; Buchsbaum, DJ; Piazza, GA

Piazza, GA (通讯作者),Auburn Univ, Harrison Sch Pharm, Dept Drug Discovery & Dev, Auburn, AL 36849 USA.

RAS: Past, Present, and Future, 2022; 153 (): 131

Abstract

Mutations in the three RAS oncogenes are present in approximately 30% of all human cancers that drive tumor growth and metastasis by aberrant activati......

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