O-6-methylguanine DNA methyltransferase is upregulated in malignant transformation of gastric epithelial cells via its gene promoter DNA hypomethylation

Chen, YX; He, LL; Xiang, XP; Shen, J; Qi, HY

Qi, HY (通讯作者)，Zhejiang Univ, Univ Sch Med, Affiliated Hosp 2, Dept Pathol & Pathophysiol, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.;Qi, HY (通讯作者)，Zhejiang Univ, Univ Sch Med, Affiliated Hosp 2, Dept Radiat Oncol, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2022; 14 (3): 664

Abstract

BACKGROUND O-6-methylguanine-DNA methyltransferase (MGMT) is a suicide enzyme that repairs the mispairing base O-6-methyl-guanine induced by environme......

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