Synthesis and anti-HCV activity of beta-D-2 '-deoxy-2 '-alpha-chloro-2 '-beta-fluoro and beta-D-2 '-deoxy-2 '-alpha-bromo-2 '-beta-fluoro nucleosides and their phosphoramidate prodrugs

Ovadia, R; Khalil, A; Li, H; De Schutter, C; Mengshetti, S; Zhou, SM; Bassit, L; Coats, SJ; Amblard, F; Schinazi, RF

Schinazi, RF (reprint author), Emory Univ, Sch Med, Dept Pediat, Ctr AIDS Res,Lab Biochem Pharmacol, Atlanta, GA 30322 USA.

BIOORGANIC & MEDICINAL CHEMISTRY, 2019; 27 (4): 664

Abstract

We report herein the synthesis and evaluation of a series of beta-D-2'-deoxy-2'-alpha-chloro-2'-beta-fluoro and beta-D-2'deoxy-2'-alpha-bromo-2'-beta-......

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