A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology

Fu, HJ; Possenti, A; Freer, R; Nakano, Y; Villegas, NCH; Tang, MP; Cauhy, PVM; Lassus, BA; Chen, S; Fowler, SL; Figueroa, HY; Huey, ED; Johnson, GVW; Vendruscolo, M; Duff, KE

Fu, HJ; Duff, KE (reprint author), Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10032 USA.; Fu, HJ; Duff, KE (reprint author), Columbia Univ, Dept Pathol & Cell Biol, Med Ctr, New York, NY 10032 USA.; Fu, HJ (reprint author), Ohio State Univ,

NATURE NEUROSCIENCE, 2019; 22 (1): 47

Abstract

Excitatory neurons are preferentially impaired in early Alzheimer's disease but the pathways contributing to their relative vulnerability remain large......

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