KRAS-driven model of Gorham-Stout disease effectively treated with trametinib

Homayun-Sepehr, N; McCarter, AL; Helaers, R; Galant, C; Boon, LM; Brouillard, P; Vikkula, M; Dellinger, MT

Dellinger, MT (corresponding author), UT Southwestern Med Ctr, 6000 Harry Hines Blvd, Dallas, TX 75390 USA.; Vikkula, M (corresponding author), Univ Louvain, de Duve Inst, Ave Hippocrate 74 5,Bte B1-74-06, B-1200 Brussels, Belgium.

JCI INSIGHT, 2021; 6 (15):

Abstract

Gorham-Stout disease (GSD) is a sporadically occurring lymphatic disorder. Patients with GSD develop ectopic lymphatics in bone, gradually lose bone, ......

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