Efficient Preparation of (S)-N-Boc-3-Hydroxylpiperidine Through Bioreduction by a Thermostable Aldo-KetoReductase

He, MY; Zhou, S; Cui, ML; Jin, XL; Lai, DY; Zhang, SL; Wang, ZG; Chen, ZM

Chen, ZM (reprint author), Hangzhou Normal Univ, Lab Biocatalysis, Hangzhou 311121, Zhejiang, Peoples R China.; Wang, ZG (reprint author), Hangzhou Normal Univ, Sch Med, Inst Aging Res, Hangzhou 311121, Zhejiang, Peoples R China.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2017; 181 (4): 1304

Abstract

(S)-N-Boc-3-hydroxypiperidine ((S)-NBHP) is a key pharmaceutical intermediate and the chiral source in synthesizing Imbruvica, which is a newly approv......

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