Redox induces diverse effects on recombinant human wild-type PrP and mutated PrP with inserted or deleted octarepeats

Shi, Q; Chen, C; Zhang, BY; Zhou, W; Xiao, K; Dong, XP

Dong, XP (reprint author), Zhejiang Univ, State Key Lab Infect Dis Prevent & Control, Collaborat Innovat Ctr Diag & Treatment Infect Di, Natl Inst Viral Dis Control & Prevent,Chinese Ctr, 155 Chang Bai Rd, Beijing 102206, Peoples R China.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2018; 41 (4): 2413

Abstract

Normal prion protein (PrP) contains two cysteines at amino acids 179 and 214, which may form intra- and interpeptide disulfide bonds. To determine the......

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