Co-immunization with hemagglutinin stem immunogens elicits cross-group neutralizing antibodies and broad protection against influenza A viruses

Moin, SM; Boyington, JC; Boyoglu-Barnum, S; Gillespie, RA; Cerutti, G; Cheung, CS; Cagigi, A; Gallagher, JR; Brand, J; Prabhakaran, M; Tsybovsky, Y; Stephens, T; Fisher, BE; Creanga, A; Ataca, S; Rawi, R; Corbett, KS; Crank, MC; Hedestam, GBK; Gorman, J; McDermott, AB; Harris, AK; Zhou, TQ; Kwong, PD; Shapiro, L; Mascola, JR; Graham, BS; Kanekiyo, M

Kanekiyo, M (通讯作者)，NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.

IMMUNITY, 2022; 55 (12): 2405

Abstract

Current influenza vaccines predominantly induce immunity to the hypervariable hemagglutinin (HA) head, requiring frequent vaccine reformulation. Conve......

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