A Simple and Efficient Method to Generate Dual Site-Specific Conjugation ADCs with Cysteine Residue and an Unnatural Amino Acid

Zhang, L; Wang, ZW; Wang, ZY; Luo, F; Guan, MF; Xu, MM; Li, YD; Zhang, YY; Wang, ZY; Wang, WY

Wang, ZY; Wang, WY (corresponding author), Chinese Acad Sci, Shanghai Inst Organ Chem, Ctr Excellence Mol Synth, Interdisciplinary Res Ctr Biol & Chem, Shanghai 201210, Peoples R China.; Wang, ZY; Wang, WY (corresponding author), Univ Chinese Acad Sci, Beijing 100049, Peoples R China.; Wang, WY (corresponding author), Fudan Univ, Huashan Hosp, Dept Rehabil Med, Shanghai 200040, Peoples R China.

BIOCONJUGATE CHEMISTRY, 2021; 32 (6): 1094

Abstract

Antibody-drug conjugates (ADCs) are complex pharmaceutical molecules that combine monoclonal antibodies with biologically active drugs through chemica......

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