Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer

Dasgupta, S; Rajapakshe, K; Zhu, BK; Nikolai, BC; Yi, P; Putluri, N; Choi, JM; Jung, SY; Coarfa, C; Westbrook, TF; Zhang, XHF; Foulds, CE; Tsai, SY; Tsai, MJ; O'Malley, BW

Dasgupta, S; O'Malley, BW (reprint author), Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA.; Dasgupta, S (reprint author), Roswell Pk Comprehens Canc Ctr, Dept Cell Stress Biol, Buffalo, NY 14263 USA.

NATURE, 2018; 556 (7700): 249

Abstract

Alterations in both cell metabolism and transcriptional programs are hallmarks of cancer that sustain rapid proliferation and metastasis(1). However, ......

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