Filling a nick in NIK: Extending the half-life of a NIK inhibitor through structure-based drug design

Crawford, JJ; Feng, JW; Brightbill, HD; Johnson, AR; Wright, M; Kolesnikov, A; Lee, W; Castanedo, GM; Do, S; Blaquiere, N; Staben, ST; Chiang, PC; Fan, PW; Baumgardner, M; Wong, SS; Godemann, R; Grabbe, A; Wiegel, C; Sujatha-Bhaskar, S; Hymowitz, SG; Liau, N; Hsu, PL; McEwan, PA; Ismaili, MHA; Landry, ML

Crawford, JJ (通讯作者)，Genentech Inc, 1 DNA Way, South San Francisco, CA 94080 USA.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023; 89 ():

Abstract

Inhibition of NF-?B inducing kinase (NIK) has been pursued as a promising therapeutic target for autoimmune disorders due to its highly regulated role......

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