Peroxynitrite/PKR Axis Modulates the NLRP3 Inflammasome of Cardiac Fibroblasts

Lan, T; Tao, AB; Xu, XM; Kvietys, P; Rui, T

Rui, T (corresponding author), Jiangsu Univ, Div Cardiol, Dept Med, Affiliated Peoples Hosp, Zhenjiang, Jiangsu, Peoples R China.; Rui, T (corresponding author), Lawson Hlth Res Inst, Crit Illness Res, London, ON, Canada.; Rui, T (corresponding author), Western Univ, Schulich Sch Med & Dent, Crit Care Western, London, ON, Canada.; Rui, T (corresponding author), Western Univ, Schulich Sch Med & Dent, Dept Med, London, ON, Canada.; Rui, T (corresponding author), Western Univ, Schulich Sch Med & Dent, Dept Pathol, London, ON, Canada.; Rui, T (corresponding author), Western Univ, Schulich Sch Med & Dent, Dept Lab Med, London, ON, Canada.

FRONTIERS IN IMMUNOLOGY, 2020; 11 ():

Abstract

Sepsis/endotoxemia activates the NLRP3 inflammasome of macrophages leading to the maturation and release of IL-1 beta, an important mediator of the in......

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