Afatinib Exerts Immunomodulatory Effects by Targeting the Pyrimidine Biosynthesis Enzyme CAD

Tu, HF; Ko, CJ; Lee, CT; Lee, CF; Lan, SW; Lin, HH; Lin, HY; Ku, CC; Lee, DY; Chen, IC; Chuang, YH; Del Cano-Ochoa, F; Ramon-Maiques, S; Ho, CC; Lee, MS; Chang, GD

Lee, MS (corresponding author), Natl Taiwan Univ, Dept Biochem & Mol Biol, Coll Med, R817 Basic Res Bldg, Taipei 100, Taiwan.; Ho, CC (corresponding author), Natl Taiwan Univ Hosp, Dept Internal Med, 7 Chung Shan South Rd, Taipei 100, Taiwan.

CANCER RESEARCH, 2021; 81 (12): 3270

Abstract

Current clinical trials of combined EGFR- tyrosine kinase inhibitors (TKI) and immune checkpoint blockade (ICB) therapies show no additional effect. T......

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