Insight into resistance mechanisms of AZD4547 and E3810 to FGFR1 gatekeeper mutation via theoretical study

Liang, DL; Chen, QW; Guo, YJ; Zhang, T; Guo, WT

Zhang, T (reprint author), Wenzhou Med Univ, Affiliated Hosp 1, Dept Rheumatol, Wenzhou 325000, Zhejiang, Peoples R China.

DRUG DESIGN DEVELOPMENT AND THERAPY, 2017; 11 ( ): 451

Abstract

Inhibitors targeting the amplification of the fibroblast growth factor receptor 1 (FGFR1) have found success in the treatment of FGFR1-positive squamo......

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